A human brain has around 1011 neurons and 1015 synapses.
It was known that the electrical communications that take place
between the brain's nerve cells, or neurons, do not occur alone. Neurons
possess branches like little trees, and when an electrical message
reaches the end of one of these branches it radiates outward as does the
ripple in a pond.
We possess Transference of learned skills, i.e. we can
write words with our left elbow.
On the brain and hallucination
Konorski conceived of a dynamical system which, he wrote, "can generate
perceptions, images and hallucinations ... the mechanism producing
hallucinations is built into our brains, but it can be thrown into
operation only in some exceptional conditions." Konorski brought
together evidence - weak in the 1960s, but overwhelming now - that there
are not only afferent connections going from the sense organs to the
brain, but 'retro' connections going in the other direction. They
provide, Konorski felt, the essential anatomical and physiological means
by which hallicunations can be generated.
What then normally prevents this from happening? The crucial factor,
Konorski suggested, is the sensory input from the eyes, ears and other
sense organs, which normally inhibits any backflow of activity from the
highest parts of the cortex to the periphery. But if there is a critical
deficiency of input from the sense organs, this will facilitate a
backflow, producing hallicunations physiologically and subjectively
indistinguishable from perceptions. (There is normally no such reduction
of input in conditions of silence or darkness because "off-units" fire
up and produce continuous activity).
On brain cell loss
Most estimates say we have about 100 billion brain cells (neurons),
and about ten times that many, or one trillion, support cells (glia)
that help the neurons. We'll just concentrate on the neurons themselves.
The brain weighs about 3 pounds, and after age 20, you lose about a
gram of brain mass per year. So if the brain weighs 1400 grams and there
are about 100 billion neurons, that comes to about 70 million neurons
per gram. Now we could stop here and say that we lose 70 million neurons
a year, or about 190,000 per day, but that wouldn't really be right.
That's because most of that gram isn't really neurons dying. Some of
that loss is glia (support cells) dying, some of it is because the
neurons are shrinking but not dying, and some of it is that the neurons
lose some of their insulation (myelin), which makes them slower, but
doesn't cause them to die.
Even if we say that only 5% of the gram is neurons actually dying, we
get neuron loss of about 9,000 neurons a day!
A side note: This is all assuming you're a person who takes care of
yourself. But there are lots of things people do that cause much higher
rates of brain cell death. The big one is using certain drugs. Not all
drugs cause brain cells to die, but the ones that do are very damaging.
Ketamine, nitrous oxide (laughing gas) and volatile inhalants (glue,
gasoline, paint thinner) can cause brain cell death at THIRTY TIMES
normal rates - that's almost 300,000 neurons a day! And alcohol also
increases the rate of brain cell death, but less than the others.
In their study of nerves, the biologists have come to the
conclusion that nerves are very fine tubes with a complex wall which is
very thin; through this wall the cell pumps ions, so that there are
positive ions on the outside and negative ions on the inside, like a
capacitor. Now this membrane has an interesting property; if it
"discharges" in one place, i.e., if some of the ions were able to move
through one place, so that the electrical voltage is reduced there, that
electrical influence makes itself felt on the ions in the neighborhood,
and it affects the membrane in such a way that it lets the ions through
at neighboring points also. This in turn affects it farther along, etc.,
and so there is a wave of *penetrability* of the membrane which runs
down the fibers when it is "excited" at one end by stepping on the sharp
stone. This wave is somewhat analogous to a long sequence of vertical
dominoes; if the end one is pushed over, that one pushes the next, etc.
Of course, this will transmit only one message unless the dominoes are
set up again, and similarly in the nerve cell, there are processes which
pump the ions slowly out again, to get the nerve ready for the next
impulse.
... when the impulse reaches the end of the nerve, little packets
of a chemical called acetylcholine are shot off (5 or 10 molecules at a
time) and they affect the muscle fiber and make it contract ...
Left and Right side of the brain
Patients that suffer from epilepsy sometimes have their L/R Brain
connection surgically 'split' in order to prevent seizures. Testing some
of these patients suggests a kind of independent 'consciousness' for
each half of the brain:
- L side of the brain regulates the R side of the senses (R eye, ...)
- R side regulates the L side of the senses.
An object was shown to the R eye only and the patient remarked that
he could see it. But when it was shown to the L eye only, he remarked he
couldn't see it, though nevertheless he could grab the said object from
a multitude of other objects.
The right brain saw the object but couldn't interpret it. This is
done by the L Brain which is the interpreter. The Left brain doesn't
know why the Left hand (eye) is doing something - but tries to explain
it in its ongoing narative.
This often leads to the curious situation where the interpreting is
done after the fact - so it reverts forwards in time.
This suggests 2 separate systems of consciousness. The Left
hemisphere's job is to tell the story → origin of false beliefs.
the Right hemisphere has language but no syntax, e.g. it doesn't know
the difference between a venetian blind and a blind venetian. It is very
good at say, detecting a peeler in a draw of cutlery.
Dr Jill Bolte Taylor gives a most intriguing insight into the brain by
describing her experiences after suffering a stroke in her left hemisphere in
one of her video talks. She compares the 2 hemispheres with computer processors:
- The left side is the
serial processor that takes care of past, future, language. The I am separation.
- The right side is the parallel processor that handles the here and now.
Plasticity
When we think and learn, we change the connection between the nerve
cells. Freud, who really was a neurologist rather than a psychiatrist,
called this "the law of association by simultaneity". Neurons that fire
together, wire together. And neurons that fire apart, wire apart.
Synapses
Well it has been said that the number of synapses in the human brain is about a million
billion. But something we've discovered about the molecular composition of the synapses
is that they have over 1,000 different proteins within this.
If you were looking at a synapse and imagining yourself down inside the synapse amongst all
of the molecules you would see what you might call molecular machines, large sets of proteins
the sort of components which assembled together make these large molecular machines. But what
is the extraordinary thing about these molecular machines which would look like large sort of
blobs of molecules is that they're actually like computers, they're information processors,
they handle all of the information that comes from the animal's environment, they convert it
into chemical signals and they process that information in very complex and specialised ways.
Everything we hear, see, taste, touch and smell is converted into these kinds of digital
electrical codes and the synapse will pass that information from one nerve cell to the next,
which then passes it to another nerve cell and the next and in that way the information is
transported around the nervous system. But the specialised thing about the synapses is they
don't just transmit the information, they listen to the information sort of like the spy
agency that listens to your phone calls, it listens to that information as it goes past. And
then responds and does things with it and one of the most extraordinary and important things
it does it allows that information to be written down and stored in the form of memories. And
this is really a key function which synapses do.
Well that's right, in fact the brain is all about the chemistry and it is, as far as electrical
transmission and chemical transmission of information is concerned, it's at synapses where the
electrical information is turned into chemical information, the chemicals are squirted across
the synaptic cleft. These are called neuro transmitters and those neuro transmitters then
stimulate and activate the electrical activity in the next nerve cell.
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